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In memoriam: Albert S. Mildvan

Albert S. Mildvan

Albert Samuel Mildvan, an emeritus professor of biological chemistry and chemistry at the Johns Hopkins University School of Medicine, died Oct. 24 in Baltimore after a prolonged illness. He was 87.

Born in Philadelphia, Mildvan earned an A.B. in chemistry and mathematics from the University of Pennsylvania in 1953 and an M.D. from Hopkins in 1957. After postdocs at the National Institutes of Health and Cambridge University, he did an advanced postdoctoral fellowship with Mildred Cohn at the University of Pennsylvania, where he developed expertise in nuclear magnetic resonance and electron paramagnetic resonance, spectroscopic techniques that became the backbone of his research career. He was on the faculty of the University of Pennsylvania and the Institute for Cancer Research Center before returning to Baltimore in 1981 to join the Hopkins faculty.

The author of more than 270 publications covering a range of protein biochemistry and enzymology, Mildvan studied the mechanism of enzyme action and its relevance to neoplastic, cardiovascular and metabolic disease. He discovered the first Mn²⁺ metalloenzyme, pyruvate carboxylase, and made key contributions to the interpretation of the effects of site-directed mutagenesis.

Mildvan served on the editorial board of the Journal of Biological Chemistry from 1979 to 1991, and in 1988 he received the 偷拍偷窥 and 偷拍偷窥 Biology’s Herbert Sober Prize recognizing outstanding biochemical and molecular biological research.

He is survived by his wife, Patricia June Tarr Mildvan; children Heather Mildvan Pytel, Pamela Mildvan Cummins and Margo Susan Mildvan; sons-in-law Theodore R. Cummins and Eric T. Arnold; sister Donna Mildvan; and grandchildren Hannah and Benjamin Cummins and Clement Pytel.

In memoriam: Irwin Fridovich

Irwin Fridovich in his office.

Irwin Fridovich, a professor emeritus at Duke University and of the 偷拍偷窥 and 偷拍偷窥 Biology who also served on the Journal of Biological Chemistry editorial board and on the ASBMB Today editorial advisory board, died Nov. 2. He was 90 years old.

Born in 1929 in Brooklyn, New York, Fridovich attended the Bronx High School of Science and the City College of New York before earning a Ph.D. in biochemistry at the Duke University Medical Center.

Duke invited him to become a faculty member, and he remained at the university for more than 60 years. In his long and distinguished career, he published more than 500 scientific articles and discovered superoxide dismutase, or SOD, essentially founding the field of free radical biology. A November 1969 paper about SOD, written by Fridovich and then–grad student Joe M. McCord and published in the Journal of Biological Chemistry, has been cited more than 9,300 times.

Fridovich served as president of several professional societies, including the ASBMB in 1982, and earned several lifetime achievement awards. He was a member of the National Academy of Sciences and the American Academy of Arts and Sciences. In 1997, he shared the Elliott Cresson Medal from the Franklin Institute with McCord. He was appointed the James B. Duke Professor of Biochemistry in 1976.

He continued to go to Duke every weekday until about four months before his death, to read the latest scientific journals and to enjoy weekly lunches with friends and colleagues.

Fridovich was married for 59 years to the former Mollie Finkel. He is survived by his daughters, Sharon F. Freedman (Neil), and Judith L. Fridovich-Keil (Mark); brother, David Fridovich (Miriam); two grandchildren and four great-grandchildren.