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One of the great opportunities in academic science is reinventing one's research program. In my case, sabbaticals have not led to dramatic shifts in fields. Instead, they have allowed me to visit three collaborators’ labs and learn new techniques that have empowered my lab to pursue new questions.

My first “sabbatical” actually happened before I started my independent career. I was hired by the University of Massachusetts Medical School in July 2001, but my lab in the new research building would not be ready until November. So, I accepted a generous invitation to spend three months at the Institut Pasteur learning how to comb DNA, an elegant single-molecule technique that changed the way I thought about the regulation of DNA replication.

Nicholas Rhind

Fast forward 11 years: I was a tenured associate professor and interested in the biochemical mechanism underlying the regulation of DNA replication that we have characterized by DNA combing. By this time I had a family, which made a foreign sabbatical impractical. I looked closer to home, and arranged to spend a year in Johannes Walter's lab at Harvard Medical School, learning how to do replication biochemistry in frog embryo extracts. It was like being a postdoc again, trying to figure out how to make a project work in an environment with all of the support and expertise I needed.

After my first two visiting-scientist experiences, I was keen for a third. Constrained still to Eastern Massachusetts, nine years after my stint at HMS, I arranged to spend a year in Jeff Gelles’ lab at Brandeis. Gelles has pioneered single-molecule fluorescence microscopy, and I wanted to use the approach to test models we had about the loading of proteins at replication origins. I had another fantastic experience. A student has since established the technology in our lab, allowing us to test models we have been speculating about for years.

My primary takeaway: Sabbaticals are a precious resource. 

All sorts of constraints can make them tricky to pull off — I delayed my third sabbatical a few years because of funding and staffing consideration — but the effort is well worth making. I was amazed at how much time I had to think and work when I was away from my office. I knew that not having teaching or committee responsibilities would free up lots of time. An unanticipated benefit was that not reviewing papers or grants for a year created more free time, and free mental energy, than I could have imagined. And none of the journal editors or granting agencies complained. They all said, “That's great. Have fun. Let me know when you are back in your office.” 

Being local, I was able to spend one day a week at UMass to have group meetings, talk with folks and look at data. My lab carried on fine, and I am sure they would have been just as fine if I had been somewhere else, meeting by Zoom.

If you’re fortunate enough to have access to a sabbatical, don't waste it. Use it to reinvent your lab in some small way, and enjoy yourself while you do so.