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The National Institutes of Health will begin using for grant applications due Jan. 25, 2025, and beyond. So what do applicants need to know?

First of all, Mark Caprara, the executive implementation committee co-chair for NIH, reassured the scientific community at an Nov. 3, that there are few changes for investigators. NIH isn’t overhauling how applications are constructed. The framework will, however, affect how applications are evaluated.

The framework will focus the reviewer’s attention on three main questions: Should it be done? Can it be done? And will it be done?

Three-factor review process

To understand the new approach, you need to know a little about the existing one.

In the current framework, the five criteria are significance, innovation, approach, investigator(s) and environment. Each criterion is scored individually and then factored into an overall impact score.

Also, there’s another set of information that is evaluated under the banner of “additional review criteria.” (More about that later.)

The simplified criteria will focus reviewers on three central factors:

Factor 1: Importance of the research

• Reviewers will evaluate the significance and innovation.

• Reviewers will give a score between one and nine.

Factor 2: Rigor and feasibility

• Reviewers will evaluate the approach.

• Reviewers will evaluate the inclusion criteria and coding, study timelines for clinical trial applications, and plans for valid design and analysis of phase III clinical trials, all of which are currently considered additional review criteria.

• Reviewers will give a score between one and nine.

Factor 3: Expertise and resources

• Reviewers will evaluate the investigator(s) and environment.

• This factor is unscored but will be used as a binary item to determine if the expertise and environment are sufficient for the proposed project.

All three factors will be considered by reviewers when determining an overall impact score to reflect their assessment of the project exerting a “sustained, powerful influence on the research field(s) involved.”

More on ‘additional review criteria’

If applicable to the proposed project, the following items will be reviewed at the first level of the grant review process: authentication of key biological and/or chemical resources and budget and period of support. These documents will be unscored and not considered for the overall impact score.

In addition, if applicable to the proposed project, the following documents will be reviewed at the first level of the grant review process: human subject protections, vertebrate animal protections, biohazards, resubmissions, renewals and revisions. These documents will be unscored and considered for the overall impact score.

The NIH staff will also assume administrative responsibilities for the following additional review criteria documents: foreign organizations, select agents research and resource sharing plans. NIH staff will evaluate these documents at the of the review process.

How we got here

NIH developed the new framework to reduce undue influence of scientific reputation and minimize the administrative burdens for peer reviewers. 

Last year, it sought from the scientific community about a draft simplified framework.

Ann West is the associate vice president for research development and a professor at the University of Oklahoma. She leads the 偷拍偷窥 and 偷拍偷窥 Biology’s Public Affairs Advisory Committee.

“This is a big change for the NIH, reviewers and applicants alike. The () reached out to the research community, including professional societies like the ASBMB, for input while they were considering these changes.  It may take some time to adjust, but, overall, I think the simplified model will be fair and more inclusive,” West said.

The ASBMB submitted its feedback in March.

NIH the final framework Oct. 19.

Timeline for educating grant reviewers

NIH has a serving as a central repository of information, and agency officials are using various channels to inform the scientific community about the changes, including the , and .

NIH officials say they will be training in 2024 and 2025 to ensure transparency in the evaluation process. is scheduled for the spring of 2025, just before the summer review meetings.

Watch the NIH and to learn more.